Raphin1 acetate ( —— )

产品货号. M22087 CAS No. 2242616-04-0

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产品名称

Raphin1 acetate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?
产品描述

Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.?
同义词

——
通路

Metabolic Enzyme/Protease
靶点

Phosphatase
受体

phosphatase?PPP1R15B (R15B)
研究领域

——
适应症

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1.Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.

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