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Raphin1 acetate
CAS No. 2242616-04-0
Raphin1 acetate ( —— )
产品货号. M22087 CAS No. 2242616-04-0
Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥567 | 有现货 |
|
| 10MG | ￥891 | 有现货 |
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| 25MG | ￥1677 | 有现货 |
|
| 50MG | ￥2884 | 有现货 |
|
| 100MG | ￥4285 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Raphin1 acetate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?
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产品描述Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.?
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Phosphatase
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受体phosphatase?PPP1R15B (R15B)
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研究领域——
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适应症——
化学信息
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CAS Number2242616-04-0
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分子量291.13
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分子式C10H12Cl2N4O2
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纯度>98% (HPLC)
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溶解度DMSO:40 mg/mL?(137.4 mM;?Need ultrasonic)
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SMILESCC(O)=O.NC(=N)N\N=C\c1cccc(Cl)c1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.
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